HELVETICA
Serruys, NEJM 1995;333:757-63
1,141 patients, 28 sites, 7 EU countries
Design, QCA, CEC, statistics

EUROPA
Fox, Lancet 2003; 362:1-7
13,200 patients, 450 sites, 25 EU countries
Design, data management, statistics, IVUS substudy, overall co-ordination

PURSUIT
Harrington, NEJM 1998;339:436-43
12,500 patients, 351 sites, 18 USA, EU, and S-Am countries
Data management, CEC, EU co-ordination

LIPS
Serruys, JAMA 2002;287:3215-22
1,677 patients, 77 sites, 10 countries
Design, data management, statistics and co-ordination

IBIS-2
Serruys, Circulation 2008;118:1172-82
330 patients, 25 sites, 10 EU countries
Core Lab (IVUS, VH, palpography), co-ordination

APPROACH
Gerstein, Circulation 2010;121:1176-87
672 patients, 92 sites, 19 EU, USA, Asian, and S-Am countries
IVUS, co-ordination

BENESTENT
Serruys, NEJM 1994;331:489-95
520 patients, 28 sites, 9 EU and S-Am countries
Design, data management, statistics, QCA, CEC, monitoring, co-ordination

RAVEL
Morice, NEJM 2002;346:1173-80
238 patients, 19 sites, 7 EU and S-Am countries
Design, data management, QCA, CEC, statistics

ABSORB
Serruys, Lancet 2009;373:897-910
30 patients, 5 sites, 4 EU countries and New Zealand
Design, QCA, IVUS, VH, OCT, CEC

SYNTAX
Serruys, NEJM 2009;360:961-72
3,075 patients, 86 sites US & EU
Design, QCA, Syntax Score, CEC, monitoring, co-ordination

LEADERS
Windecker, Lancet 2008;372:1163–73
1707 patients, 10 sites EU, 6 months enrolment
Design, data management, QCA, Syntax Score, CEC, statistics

SOFA
Brouwer, JAMA 2006;295:2613-19
500 patients, 25 sites in EU
Data management, monitoring, ICD, ECG