The European Cardiovascular Research Institute (ECRI) offers a platform for the design and conduct of multi-center, multi-national investigator-initiated studies in cardiology. The ECRI projects started in 2012 as independent Dutch incorporations (B.V.) and sister organizations of Cardialysis, and are solely funded by grant-givers. 

Trial designs are developed in collaboration with international key opinion leaders and ECRI acts as sponsor with medical and legal accountability, ensuring compliance with ICH GCP guidelines and regulatory standards. Research funds granted by healthcare industry manufacturers are managed toward timely execution of trial activities. ECRI executes trials through Cardialysis as preferred contract research organization and works in collaboration with renowned research organizations world-wide.

Each ECRI project is overseen by a steering committee composed by eminent scientific and clinical leaders, as well as an ECRI representative. In addition, independent data and safety monitoring boards and clinical events committees, ensure patient safety, data integrity, and consistent assessment of outcomes. The ECRI projects are mentioned below:

GLOBAL LEADERS (completed)
SYNTAX II (ongoing, long-term follow-up)
ABSORB STEMI: THE TROFI II STUDY (completed)
DESSOLVE III (ongoing, long-term follow-up)
GALILEO 4D (completed)
TALENT (ongoing, long-term follow-up)
MASTER DAPT (ongoing)
POLBOS Left Main (ongoing)
OPTIMAL (ongoing)