The Cardialysis Echocardiography (ECHO) Core Lab provides adjudication of clinically validated primary and secondary endpoints in all phases of clinical trials and mechanistic insights into investigational drugs and devices. Furthermore, it provides adjudication of cardiac safety for investigational compounds.

ECHO Reading and Analysis

Cardialysis provides central independent ECHO. Analysis is performed by a team of senior technicians and cardiologists. Our ECHO team has extensive expertise in clinical trial design and execution. All analyses are based on the state-of-the-art American Society of Echocardiography, European Association of Cardiovascular Imaging, and Academic Research Consortium recommendations and guidelines. 

Cardialysis provides analysis of Doppler, 1D, 2D, and 3D echocardiographic modalities. ECHO analysis is currently being used in use for structural heart and heart failure clinical trials. Data from a number of these trials are used for both CE mark and FDA submissions.

ECHO Core Lab services are currently used in the following analyses:

  • Percutaneous Aortic Valves Implantation (TAVI)
  • Surgical prosthetic valve replacement
  • LAA occlusion devices
  • Cardiac resynchronization therapy
  • Heart failure investigational compounds


The ECHO Core Lab provides the following analyses:

Cardiac structure and function
  • 2D LV size (dimensions, areas, and volumes)
  • 2D LV ejection fraction
  • 2D & M-mode assessment of LV mass
  • 2D LV regional wall motion
  • 2D assessment of left atrial size, function

Physiologic and hemodynamic assessment
  • Doppler comprehensive hemodynamic assessments
  • Quantification of mitral regurgitation
  • Quantification of aortic regurgitation
  • Quantification of pulmonary regurgitation
  • Quantification of tricuspid regurgitation
  • 2D stress echocardiography and contractile reserve
  • Tissue Doppler quantitative myocardial function

Together with our industry partners, we are developing vendor-independent techniques for the following Core Lab services:
  • 2D speckle-tracking deformation imaging
  • 3D LV volumes and EF
  • 3D RV volumes and EF (vendor-independent)
  • 3D aortic and mitral regurgitation
  • Contrast echocardiography (perfusion/wall motion)

Literature references