(Track record and methodological references: Core Lab Publications)

The Cardialysis Echocardiography (Echo) Core Lab enables adjudication of clinically validated primary and secondary endpoints in all phases of clinical trials associated with mechanistic insights into investigational drugs and devices. Furthermore, it enables adjudication of cardiac safety for investigational compounds.

Echo Reading and Analysis

Cardialysis provides central independent Echo analysis. A team of senior technicians and cardiologists performs the analyses. This Echo team has extensive expertise in clinical study design and execution. All analyses are based on state-of-the-art recommendations and guidelines from the American Society of Echocardiography, European Association of Cardiovascular Imaging, and the Academic Research Consortium. 

Cardialysis provides analysis of Doppler, 1D, 2D, and 3D echocardiographic modalities. Echo analysis is currently being used to investigate structural heart and heart failure. Data from a number of these studies were used for either CE marking or drug registration.

Our Echo Core Lab services are currently used in the following interventions:

  • Transcatheter aortic valve replacement (TAVR)
  • Transcatheter tricuspid and mitral therapies (TTMT)
  • Surgical prosthetic valve replacement
  • Left atrial appendage occlusion devices
  • Cardiac resynchronization therapy
  • Heart failure investigational compounds


The Echo Core Lab provides the following analyses:

Cardiac structure and function
  • 2D LV size (dimensions, areas, and volumes)
  • 2D LV ejection fraction
  • 2D & M-mode assessment of LV mass
  • 2D LV regional wall motion
  • 2D assessment of left atrial size, function
  • 2D deformation imaging (strain analysis)

Physiologic and hemodynamic assessment
  • Doppler comprehensive hemodynamic assessments
  • Quantification of mitral regurgitation
  • Quantification of aortic regurgitation
  • Quantification of pulmonary regurgitation
  • Quantification of tricuspid regurgitation
  • 2D stress echocardiography and contractile reserve
  • Tissue Doppler quantitative myocardial function

Together with our industry partners, we are developing vendor-independent techniques for the following Core Lab services:
  • 2D speckle-tracking deformation imaging
  • 3D LV volumes and ejection fraction 
  • 3D RV volumes and ejection fraction
  • 3D aortic and mitral regurgitation
  • Contrast echocardiography (perfusion/wall motion)